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KMID : 1234920170170020119
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Journal of Korean Oriental Association for Study of Obesity
2017 Volume.17 No. 2 p.119 ~ p.126
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The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice
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Song Mi-Young
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Abstract
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Objectives: This study investigated the effects of the mixed herbal extract from Cinnamomum cassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, and Aconitum carmichaeli Debx (CAPA) on obesity and glucose tolerance in obese mice.
Methods: Animals were divided in 6 groups, normal diet, high fat diet (HFD), HFD with CAPA 100 mg/kg (CAPA 100), CAPA 300 mg/kg (CAPA 300), and metformin 200 mg/kg or lorcaserin 10 mg/kg as positive controls, and treated for 16 weeks. Body weight, food intake, fasting blood glucose, and body temperature were checked every week and then organs, blood serums were collected after treatment. The oral glucose tolerance test was also carried out after treatment.
Results; Compared to HFD, CAPA extract treated mice showed significant decreases in body weight, adipose tissue weight, lipid accumulations in liver and serum lipid levels without a reduction of food intake. And fasting glucose and glucose tolerance were all improved in the CAPA treated mice.
Conclusions; Our results suggest that CAPA extract can prevent diet induced obesity and glucose intolerance without a reduction of energy intake in obese mice.
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KEYWORD
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Cinnamomum cassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, Aconitum carmichaeli Debx, Obesity, Glucose
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